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Literature summary for 4.2.1.123 extracted from

  • Banta, A.B.; Wei, J.H.; Welander, P.V.
    A distinct pathway for tetrahymanol synthesis in bacteria (2015), Proc. Natl. Acad. Sci. USA, 112, 13478-13483 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.123

Application

Application Comment Organism
diagnostics tetrahymanol is a polycyclic triterpenoid lipid in the Tetrahymena ciliates. The diagenetic product, gammacerane, is often used as a biomarker for water column stratification in ancient ecosystems Tetrahymena thermophila

Cloned(Commentary)

Cloned (Comment) Organism
gene ths, DNA and amino acid sequence determination and analysis, sequence comparisons Tetrahymena thermophila

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
squalene + H2O Tetrahymena thermophila
-
 tetrahymanol
-
 ?
squalene + H2O Tetrahymena thermophila SB210
-
 tetrahymanol
-
 ?

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila Q24FB1
-
-
Tetrahymena thermophila SB210 Q24FB1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene + H2O
-
 Tetrahymena thermophila tetrahymanol
-
 ?
squalene + H2O
-
 Tetrahymena thermophila SB210 tetrahymanol
-
 ?

Synonyms

Synonyms Comment Organism
squalene-tetrahymanol cyclase
-
 Tetrahymena thermophila
STC
-
 Tetrahymena thermophila

General Information

General Information Comment Organism
evolution the eukaryotic squalene-tetrahymanol cyclase is homologous to the bacterial tetrahymanol synthase (Ths), that is not encoded in any eukaryotic genomes. Bacterial tetrahymanol synthase (Ths) is found in a variety of bacterial genomes, including aerobic methanotrophs, nitrite-oxidizers, and sulfate-reducers, and in a subset of aquatic and terrestrial metagenomes Tetrahymena thermophila
physiological function eukaryotic squalene-tetrahymanol cyclase catalyzes the cyclization of squalene directly to tetrahymanol, a polycyclic triterpenoid lipid, the enzyme catalyzes the cyclization of squalene directly to tetrahymanol Tetrahymena thermophila